Alpha-halocarboxylic acids and derivatives
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Filtered Search Results
AdipoGen GE23077 A1 B1
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Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
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Medchemexpress LLC Acetic acid, 2-iodo-, 1,1'-anhydride | 54907-61-8 | MFCD00001080 | 70.0% | 353.88 | C4H4I2O3 | 50 MG
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Iodoacetic anhydride is an acylating reagent used in organic synthesis and biochemical research for selective modification of thiol groups and protein labelling. It is supplied as a brown to dark brown solid and should be handled under anhydrous conditions with appropriate cold storage to preserve stability.
- Acylating reagent for protein modification and organic synthesis.
- Contains 2-iodoacetyl functionality for selective alkylation of thiols.
- Provided as a brown to dark brown solid suitable for analytical use.
- Reported purity: 70.0%.
- Recommended storage: cold, anhydrous conditions to maintain stability.
- Handle in a fume hood with appropriate personal protective equipment.
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Selleck Chemical LLC BIBO 3304 Trifluoroacetate
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BIBO 3304 Trifluoroacetate (BIBO-3304 TFA) is a novel neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 values of 0 38 nM and 0 72 nM for human Y1 receptor and rat Y1 receptor respectively BIBO 3304 shows low affinity for the human Y2 receptor human and rat Y4 receptor as well as for the human and rat Y5 receptor (IC50 values 1000 nM)
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eMolecules EMOLECULES INC
5000472243 M-BROMOPHENYLACETIC ACID 500G
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eMolecules EMOLECULES INC
5000488975 3-BROMOPHENYLACETIC ACID 100G
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Chem-Impex International, Inc. Dichloroacetic acid | MFCD00004223 | 100G
Dichloroacetic acid, MFCD00004223, 100G
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AdipoGen Rhodamine 6G p-DAX amide bis
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Chemical. CAS 591742-78-8. Formula C34H36N4O2 . C4H2F6O4. MW 760.72. Synthetic. Fluorescent labelling.
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eMolecules Pharmablock Difluoroacetic Anhydride 250mg 795394260 PBT4711 0 000 401-67-2 MFCD02093315 174 051 C4H2F4O3
Pharmablock Difluoroacetic Anhydride 250mg 795394260 PBT4711 0 000 401-67-2 MFCD02093315 174 051 C4H2F4O3
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Cayman Chemical W146 trifluoroacetate salt
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An S1P1 receptor antagonist (Ki = 77 nM); selective for S1P1 over S1P2, S1P3, and S1P5 (Kis = >10 µM); prevents ligand-induced receptor internalization in CHO cells and inhibits ERK and Akt phosphorylation at 10 µM; increases AMD3100-induced KSL-HSPC entrance into mouse blood circulation from the bone marrow at 5 mg/kg in combination with AMD3100; disrupts the endothelial barrier and induces PMN neutrophil infiltration into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury at 10 UG intranasally or intradermally
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eMolecules DIFLUOROACETIC ANHYDRIDE 1G
5000224030 DIFLUOROACETIC ANHYDRIDE 1G
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Cayman Chemical W146 trifluoroacetate salt
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An S1P1 receptor antagonist (Ki = 77 nM); selective for S1P1 over S1P2, S1P3, and S1P5 (Kis = >10 µM); prevents ligand-induced receptor internalization in CHO cells and inhibits ERK and Akt phosphorylation at 10 µM; increases AMD3100-induced KSL-HSPC entrance into mouse blood circulation from the bone marrow at 5 mg/kg in combination with AMD3100; disrupts the endothelial barrier and induces PMN neutrophil infiltration into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury at 10 UG intranasally or intradermally
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Cayman Chemical FAmidine trifluoroacetate sa
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A PAD inhibitor (IC50s = 29.5 and 350 µM for PAD1 and PAD3, respectively, in vitro; irreversibly inactivates four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively)
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000360580 EMAPTICAP PEGOL SOD 1MG
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Cayman Chemical 3 4DHMA trifluoroacetate sal
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An analytical reference standard categorized as an amphetamine; an active metabolite of 3,4-MDMA; intended for research and forensic applications
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eMolecules BROMOACETIC ACID N-HYDROXY 25G
5000160026 BROMOACETIC ACID N-HYDROXY 25G
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