Alpha-halocarboxylic acids and derivatives

Organic compounds that contain a carboxyl group bonded to a halogen group in the alpha position; halogen groups consist of one or more halogen atoms (F, Cl, B, I, At). Includes compounds that are derived from alpha-halocarboxylic acids.

Search Within Results

451 – 465 of 567 results

451

Cayman Chemical W140 trifluoroacetate salt

An inactive enantiomer of W146; binds weakly to S1P1 (Ki = 4.6 µM for the human receptor); has been used as a negative control in the study of S1P1 receptor signaling

Pricing & Availability

452

Cayman Chemical trifluoroacetate salt 5mg

A derivative of GLP-1

Pricing & Availability

453

Medchemexpress LLC GRA Ex-25 | 307983-31-9 | 99.1% | C29H36F3N3O5 | 5 MG

GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. It binds a human glucagon receptor (h-GlucRbind) with a Ki of 63 nM and shows moderate glucagon-induced adenylate cyclase inhibition (h-GlucRcyclase) with a Ki of 254 nM. It significantly reduces blood glucose caused by exogenous administration of glucagon in a rat model by inhibiting the rise in blood glucose levels elicited by exogenously administered glucagon, most likely due to direct inhibition of glucagon-stimulated hepatic glucose output. Intended for research use only.

Inhibits glucagon receptor.
IC50 of 56 nM for rat glucagon receptors.
IC50 of 55 nM for human glucagon receptors.
Binds human glucagon receptor with a Ki of 63 nM.
Shows moderate glucagon-induced adenylate cyclase inhibition with a Ki of 254 nM.
Significantly reduces blood glucose in a rat model.